A Glance on Ageing, Longevity & the Roles of Free Radicals
Keywords:
Ageing, oxidation, antioxidants, free radicalsAbstract
This paper explores the intricate relationship between aging, cellular dynamics, and oxidative stress, emphasizing the role of free radicals and reactive oxygen species (ROS) in the aging process. It traces the historical context of longevity, highlighting the significant increase in life expectancy over the centuries and the biological mechanisms underlying aging, including mitochondrial DNA mutations and cellular senescence. Recent findings from the Okinawa Institute of Science and Technology reveal a crucial link between cell membrane integrity and aging, demonstrating how mechanical damage to membranes can influence cell fate and senescence. The research further investigates the impact of free radicals generated during metabolic processes and their contribution to cellular damage, leading to accelerated aging. The role of thiol groups, particularly in biomolecules like cysteine and glutathione, is examined for their antioxidant properties and significance in maintaining cellular health. The paper concludes that aging is a cumulative response to various stressors, both internal and external, underscoring the need for future research focused on therapeutic interventions that enhance cellular repair mechanisms and promote healthy longevity. Understanding these molecular underpinnings can inform strategies aimed at improving the quality of life and extending health spans in aging populations.
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